Clonal proliferation of T-Cell large granular lymphocytes.


BACKGROUND T-cell large granular lymphocyte (T-LGL) leukemia is a disorder only rarely reported in children. We diagnosed a new case of a clonal T-LGL proliferation in a 6-year-old girl presenting with severe neutropenia and pure red blood cell aplasia (PRCA). PROCEDURE Flow cytometric analysis including TCR-Vbeta repertoire analysis and molecular studies… (More)