Clonal populations of T-cells in patients with B-cell malignancies.

@article{Moss1997ClonalPO,
  title={Clonal populations of T-cells in patients with B-cell malignancies.},
  author={Paul A. H. Moss and G A Gillespie},
  journal={Leukemia & lymphoma},
  year={1997},
  volume={27 3-4},
  pages={231-8}
}
Patients with B-cell malignancies are often immunosuppressed and have defective T-cell function in vitro. In addition they frequently have unusual T-cell populations in the peripheral blood including an increase in the number of activated T-cells and an inverted CD4:CD8 ratio. More recently several reports have documented the presence of large, monoclonal populations of T-cells in patients with paraproteinaemia, B-CLL and hairy cell leukemia. Such cells can reach very high levels in the… CONTINUE READING

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