Clonal origin of atypical adenomatous hyperplasia of the liver and clonal identity with hepatocellular carcinoma.

We present details of two separate nodular lesions of atypical adenomatous hyperplasia, within one of which a small area of overt hepatocellular carcinoma was detected. The patient was positive for serum hepatitis B surface antigen, and Southern blot analysis revealed that deoxyribonucleic acid from the lesions of hepatocellular carcinoma and surrounding… CONTINUE READING