Clonal karyotype abnormalities and clinical progress in the myelodysplastic syndrome.

@article{Geddes1990ClonalKA,
  title={Clonal karyotype abnormalities and clinical progress in the myelodysplastic syndrome.},
  author={Andrew Geddes and David T. Bowen and Andrew Tsay Jacobs},
  journal={British journal of haematology},
  year={1990},
  volume={76 2},
  pages={
          194-202
        }
}
Clonal karyotype abnormalities in 124 patients with myelodysplastic syndrome are reviewed. 36% of patients had abnormalities at referral, the most common being 5q-, +8 and lesions of chromosomes 7 and 20. Reduced survival was associated with the presence of either single or multiple clonal abnormalities at referral, abnormalities of chromosome 7 or 8 (either alone or with other lesions) and exclusively abnormal metaphases. The presence of 5q- alone did not appear to affect survival. Sequential… CONTINUE READING
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