Clonal integration of a polyomavirus in human Merkel cell carcinoma.

  title={Clonal integration of a polyomavirus in human Merkel cell carcinoma.},
  author={Huichen Feng and Masahiro Shuda and Yuan Chang and Patrick S Moore},
  volume={319 5866},
Merkel cell carcinoma (MCC) is a rare but aggressive human skin cancer that typically affects elderly and immunosuppressed individuals, a feature suggestive of an infectious origin. We studied MCC samples by digital transcriptome subtraction and detected a fusion transcript between a previously undescribed virus T antigen and a human receptor tyrosine phosphatase. Further investigation led to identification and sequence analysis of the 5387-base-pair genome of a previously unknown polyomavirus… CONTINUE READING
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