Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages

@article{Seaberg2004ClonalIO,
  title={Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages},
  author={R. Seaberg and S. Smukler and T. J. Kieffer and G. Enikolopov and Z. Asghar and M. Wheeler and G. Korbutt and D. Kooy},
  journal={Nature Biotechnology},
  year={2004},
  volume={22},
  pages={1115-1124}
}
The clonal isolation of putative adult pancreatic precursors has been an elusive goal of researchers seeking to develop cell replacement strategies for diabetes. We report the clonal identification of multipotent precursor cells from the adult mouse pancreas. The application of a serum-free, colony-forming assay to pancreatic cells enabled the identification of precursors from pancreatic islet and ductal populations. These cells proliferate in vitro to form clonal colonies that coexpress neural… Expand
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