Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice.


Human aging is associated with an increased frequency of somatic mutations in hematopoietic cells. Several of these recurrent mutations, including those in the gene encoding the epigenetic modifier enzyme TET2, promote expansion of the mutant blood cells. This clonal hematopoiesis correlates with an increased risk of atherosclerotic cardiovascular disease… (More)
DOI: 10.1126/science.aag1381