Clonal genomic alterations in glioma malignancy stages.

  title={Clonal genomic alterations in glioma malignancy stages.},
  author={C. David James and Elisabeth Carlbom and Jan P. Dumanski and Mogens Hansen and Magnus Nordenskjold and Vincent Peter Collins and Webster K Cavenee},
  journal={Cancer research},
  volume={48 19},
Comparison of constitutional and tumor genotypes at chromosomal loci defined by restriction fragment length alleles has proven useful in determining the genomic position and tissue specificity of recessive mutations that predispose to cancer (Hansen, M.F., and Cavenee, W.K. Cancer Res., 47:5518-5527, 1987). Here we have applied this approach to 53 unrelated patients with glial tumors of varying histological malignancy grade. Loss of constitutional heterozygosity for loci on chromosome 10 was… CONTINUE READING
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