Clonal expansion of p53 mutant cells is associated with brain tumour progression

@article{Sidransky1992ClonalEO,
  title={Clonal expansion of p53 mutant cells is associated with brain tumour progression},
  author={David Sidransky and T. G. Mikkelsen and Karl Schwechheimer and Mark L. Rosenblum and Web Cavanee and Bert Vogelstein},
  journal={Nature},
  year={1992},
  volume={355},
  pages={846-847}
}
TUMOUR progression is a fundamental feature of the biology of cancer1. Cancers do not arise de novo in their final form, but begin as small, indolent growths, which gradually acquire characteristics associated with malignancy. In the brain, for example, low-grade tumours (astrocytomas) evolve into faster growing, more dysplastic and invasive high-grade tumours (glioblastomas)2,3. To define the genetic events underlying brain tumour progression, we analysed the p53 gene in ten primary brain… CONTINUE READING

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