Clonal expansion of genome-intact HIV-1 in functionally polarized Th1 CD4+ T cells.

@article{Lee2017ClonalEO,
  title={Clonal expansion of genome-intact HIV-1 in functionally polarized Th1 CD4+ T cells.},
  author={Guinevere Q Lee and Nina Orlova-Fink and Kevin Einkauf and Fatema Z Chowdhury and Xiaoming Sun and Sean Harrington and Hsiao-Hsuan Kuo and Stephane Hua and Hsiao-Rong Chen and Zhengyu Ouyang and K. Ram Chandra Reddy and Krista Dong and Thumbi Ndung'u and Bruce D. Walker and E. S. Rosenberg and Xu G. Yu and Mathias Lichterfeld},
  journal={The Journal of clinical investigation},
  year={2017},
  volume={127 7},
  pages={2689-2696}
}
HIV-1 causes a chronic, incurable disease due to its persistence in CD4+ T cells that contain replication-competent provirus, but exhibit little or no active viral gene expression and effectively resist combination antiretroviral therapy (cART). These latently infected T cells represent an extremely small proportion of all circulating CD4+ T cells but… CONTINUE READING