Clonal expansion of T lymphocytes causes arthritis and mortality in mice infected with toxic shock syndrome toxin-1-producing staphylococci.

@article{Abdelnour1994ClonalEO,
  title={Clonal expansion of T lymphocytes causes arthritis and mortality in mice infected with toxic shock syndrome toxin-1-producing staphylococci.},
  author={Arturo Abdelnour and Tomas Bremell and Rikard Holmdahl and Andrej Tarkowski},
  journal={European journal of immunology},
  year={1994},
  volume={24 5},
  pages={
          1161-6
        }
}
Erosive arthritis is a common and feared complication of staphylococcal infection. The reason(s) for the progressive course of the arthritis is unknown. It has been recently established that enterotoxins produced by Staphylococcus aureus display superantigen properties leading to stimulation of T cells carrying distinct T cell receptor V beta elements. This finding provides a potential connection between staphylococcal exoproteins and endogenous immune mechanisms participating in the infectious… CONTINUE READING
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