Clonal expansion and somatic hypermutation of V(H) genes of B cells from cerebrospinal fluid in multiple sclerosis.

@article{Qin1998ClonalEA,
  title={Clonal expansion and somatic hypermutation of V(H) genes of B cells from cerebrospinal fluid in multiple sclerosis.},
  author={Yuan Qin and Pierre Duquette and Yulong Zhang and Pierre Talbot and Ranulph Poole and Jack P. Antel},
  journal={The Journal of clinical investigation},
  year={1998},
  volume={102 5},
  pages={1045-50}
}
The cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients is characterized by increased concentrations of immunoglobulin (Ig), which on electrophoretic analysis shows restricted heterogeneity (oligoclonal bands). CSF Ig is composed of both serum and intrathecally produced components. To examine the properties of intrathecal antibody-producing B cells, we analyzed Ig heavy-chain variable (V(H)) region genes of B cells recovered from the CSF of 12 MS patients and 15 patients with other… CONTINUE READING
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