Clonal expansion and linear genome evolution through breast cancer progression from pre-invasive stages to asynchronous metastasis

@inproceedings{Krigrd2015ClonalEA,
  title={Clonal expansion and linear genome evolution through breast cancer progression from pre-invasive stages to asynchronous metastasis},
  author={Anne Bruun Kr{\o}ig{\aa}rd and Martin J Larsen and Anne-Vibeke L{\ae}nkholm and Ann S{\o}gaard Knoop and Jeanette Dupont Jensen and Martin J. Bak and Jan Mollenhauer and Torben Arvid Kruse and Mads Thomassen},
  booktitle={Oncotarget},
  year={2015}
}
Evolution of the breast cancer genome from pre-invasive stages to asynchronous metastasis is complex and mostly unexplored, but highly demanded as it may provide novel markers for and mechanistic insights in cancer progression. The increasing use of personalized therapy of breast cancer necessitates knowledge of the degree of genomic concordance between different steps of malignant progression as primary tumors often are used as surrogates of systemic disease. Based on exome sequencing we… CONTINUE READING
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