Clonal expanded TRA and TRB subfamily T cells in peripheral blood from patients with diffuse large B-cell lymphoma.

@article{Tan2010ClonalET,
  title={Clonal expanded TRA and TRB subfamily T cells in peripheral blood from patients with diffuse large B-cell lymphoma.},
  author={Huo Tan and Jingmei Ye and Xiaodan Luo and Shaohua Chen and Qingsong Yin and Lijian Yang and Yangqiu Li},
  journal={Hematology},
  year={2010},
  volume={15 2},
  pages={81-7}
}
T cell immunodeficiency is a common feature in cancer patients and may be a contributing factor to the initiation and development of the tumor. In order to characterize the immune status in a group of patients with diffuse large B-cell lymphoma (DLBL), the repertoires of T cell receptor alpha and beta variable regions (TRAV and TRBV) were analyzed. The CDR3 of 29 TRAV and 24 TRBV subfamily genes were analyzed in peripheral blood mononuclear cells from six cases with DLBL using RT-PCR and… CONTINUE READING