Clonal evolution of glioblastoma under therapy

@article{Wang2016ClonalEO,
  title={Clonal evolution of glioblastoma under therapy},
  author={Jiguang Wang and Emanuela Cazzato and Erik Ladewig and Veronique Frattini and Daniel I S Rosenbloom and Sakellarios Zairis and F. Manfredo Abate and Zhaoqi Liu and Oliver Elliott and Yong-Jae Shin and Jin-Ku Lee and In-Hee Lee and Woong-Yang Park and Marica Eoli and Andrew J. Blumberg and Anna Lasorella and Do-Hyun Nam and Gaetano Finocchiaro and Antonio Iavarone and Raul Rabadan},
  journal={Nature Genetics},
  year={2016},
  volume={48},
  pages={768-776}
}
Glioblastoma (GBM) is the most common and aggressive primary brain tumor. To better understand how GBM evolves, we analyzed longitudinal genomic and transcriptomic data from 114 patients. The analysis shows a highly branched evolutionary pattern in which 63% of patients experience expression-based subtype changes. The branching pattern, together with estimates of evolutionary rate, suggests that relapse-associated clones typically existed years before diagnosis. Fifteen percent of tumors… CONTINUE READING
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