Clonal evolution of glioblastoma under therapy

  title={Clonal evolution of glioblastoma under therapy},
  author={J. Wang and E. Cazzato and E. Ladewig and Veronique Frattini and D. Rosenbloom and Sakellarios Zairis and F. Abate and Zhaoqi Liu and O. Elliott and Yong-Jae Shin and Jin-Ku Lee and In-Hee Lee and W. Park and M. Eoli and A. Blumberg and A. Lasorella and D. Nam and G. Finocchiaro and A. Iavarone and R. Rabadan},
  journal={Nature Genetics},
  • J. Wang, E. Cazzato, +17 authors R. Rabadan
  • Published 2016
  • Biology, Medicine
  • Nature Genetics
  • Glioblastoma (GBM) is the most common and aggressive primary brain tumor. To better understand how GBM evolves, we analyzed longitudinal genomic and transcriptomic data from 114 patients. The analysis shows a highly branched evolutionary pattern in which 63% of patients experience expression-based subtype changes. The branching pattern, together with estimates of evolutionary rate, suggests that relapse-associated clones typically existed years before diagnosis. Fifteen percent of tumors… CONTINUE READING
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