Clonal evolution and devolution after chemotherapy in adult acute myelogenous leukemia.

Abstract

The frequent occurrence of persistent or relapsed disease after induction chemotherapy in AML necessitates a better understanding of the clonal relationship of AML in various disease phases. In this study, we used SNP 6.0 array-based genomic profiling of acquired copy number aberrations (aCNA) and copy neutral LOH (cnLOH) together with sequence analysis of… (More)
DOI: 10.1182/blood-2012-04-427039

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