Clonal eosinophils are a morphologic hallmark of ETV6/ABL1 positive acute myeloid leukemia.

@article{Starza2002ClonalEA,
  title={Clonal eosinophils are a morphologic hallmark of ETV6/ABL1 positive acute myeloid leukemia.},
  author={Roberta La Starza and Maurizio Trubia and Nicoletta Testoni and Emanuela Ottaviani and Elena Belloni and Barbara Crescenzi and Massimo Fabrizio Martelli and Georges Flandrin and Pier Giuseppe Pelicci and Cristina Mecucci},
  journal={Haematologica},
  year={2002},
  volume={87 8},
  pages={789-94}
}
BACKGROUND AND OBJECTIVES The ETV6 gene undergoes rearrangements with tyrosine kinases in hematologic malignancies and solid tumors. ETV6/ABL1 chimeric proteins have been detected both in lymphoid and myeloid disorders. Our objective was to study two new cases of ETV6/ABL1-positive acute myeloid leukemia (AML) and to focus on bone marrow morphology and on molecular cytogenetics of eosinophilic cells. DESIGN AND METHODS Fluorescence in situ hybridization (FISH) was performed in two AML cases… CONTINUE READING

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A new ETV 6 / TEL partner gene , ARG ( ABL - related gene or ABL 2 ) , identified in an AML - M 3 cell line with a t ( 1 ; 12 ) ( q 25 ; p 13 ) translocation

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The tyrosine kinase abl - related gene ARG is fused to ETV 6 in an AML - M 4 Eo patient with a t ( 1 ; 12 ) ( q 25 ; p 13 ) : molecular cloning of both reciprocal transcripts

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