Clonal dynamics in a single AML case tracked for 9 years reveals the complexity of leukemia progression

@article{Kim2016ClonalDI,
  title={Clonal dynamics in a single AML case tracked for 9 years reveals the complexity of leukemia progression},
  author={Taeyoon Kim and Kenichi Yoshida and Y-K Kim and Marc S. Tyndel and Hyun Joo Park and Seung Hyun Choi and J-S Ahn and S-H Jung and Duosheng Yang and Je-Jung Lee and Hyungwon San Jose Kim and Guangyao Kong and Seishi Ogawa and Zhiyuan Zhang and Dr. Dong-Shik Kim},
  journal={Leukemia},
  year={2016},
  volume={30},
  pages={295-302}
}
Most types of cancers are made up of heterogeneous mixtures of genetically distinct subclones. In particular, acute myeloid leukemia (AML) has been shown to undergo substantial clonal evolution over the course of the disease. AML tends to harbor fewer mutations than solid tumors, making it challenging to infer clonal structure. Here, we present a 9-year, whole-exome sequencing study of a single case at 12 time points, from the initial diagnosis until a fourth relapse, including 6 remission… CONTINUE READING
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