Clonal dominance of select subsets of viral Kirsten ras(+)-transformed 3T3 cells during tumor progression.

@article{Radinsky1991ClonalDO,
  title={Clonal dominance of select subsets of viral Kirsten ras(+)-transformed 3T3 cells during tumor progression.},
  author={Robert R Radinsky and Lloyd A. Culp},
  journal={International journal of cancer},
  year={1991},
  volume={48 1},
  pages={148-59}
}
Long-term culturing of viral Kirsten-ras-oncogene (v-Ki-ras)-transformed BALB/c 3T3 cells (KiMSV) selectively enriches for cells which have deleted the viral oncogene. In contrast, v-Ki-ras in vivo is amplified and expression increased in all late-stage tumors and lung metastases relative to late-passage KiMSV cells being injected. The nature and significance of these selection processes, in terms of the v-Ki-ras gene, have been explored using genetically-tagged cells, as have the properties of… CONTINUE READING

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