Clonal dominance of primary tumours by metastatic cells: genetic analysis and biological implications.

@article{Kerbel1988ClonalDO,
  title={Clonal dominance of primary tumours by metastatic cells: genetic analysis and biological implications.},
  author={Robert S. Kerbel and C G Waghorne and Bożena Korczak and A C Lagarde and Martin L. Breitman},
  journal={Cancer surveys},
  year={1988},
  volume={7 4},
  pages={597-629}
}
A new method is described for analysing the clonal evolutionary dynamics of tumour growth and the lineage relationship of primary tumours to their metastases. It exploits random integrations of transfected plasmid or retroviral infected (proviral) DNA as a means of generating very large numbers of uniquely marked cell clones in a single-step selection whose fates can then be tracked during progressive tumour growth. Using a mouse breast adenocarcinoma we undertook experiments in which syngeneic… CONTINUE READING