Clonal dominance and transplantation dynamics in hematopoietic stem cell compartments

  title={Clonal dominance and transplantation dynamics in hematopoietic stem cell compartments},
  author={Peter Ashcroft and Markus G. Manz and Sebastian Bonhoeffer},
  journal={PLoS Computational Biology},
Hematopoietic stem cells in mammals are known to reside mostly in the bone marrow, but also transitively passage in small numbers in the blood. Experimental findings have suggested that they exist in a dynamic equilibrium, continuously migrating between these two compartments. Here we construct an individual-based mathematical model of this process, which is parametrised using existing empirical findings from mice. This approach allows us to quantify the amount of migration between the bone… 

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