Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes

@article{Nemazee1989ClonalDO,
  title={Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes},
  author={David Nemazee and Kurt H. B{\"u}rki},
  journal={Nature},
  year={1989},
  volume={337},
  pages={562-566}
}
B lymphocytes can be rendered specifically unresponsive to antigen by experimental manipulation in vivo and in vitro1–6, but it remains unclear whether or not natural tolerance involves B-cell tolerance because B cells are controlled by T lymphocytes, and in their absence respond poorly to antigen (reviewed in ref. 7). In addition, autoantibody-producing cells can be found in normal mice and their formation is enhanced by B-cell mitogens such as lipopolysaccharides8–12. We have studied B-cell… CONTINUE READING
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