Clonal cytotoxic T cells are expanded in myeloma and reside in the CD81CD571CD282 compartment


The occurrence of clonal T cells in multiple myeloma (MM), as defined by the presence of rearrangements in the T-cell receptor (TCR)–b chains detected on Southern blotting, is associated with an improved prognosis. Recently, with the use of specific anti–TCR-variable-b (anti– TCRVb) antibodies, the presence in MM patients of expanded populations of T cells… (More)


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