Clonal characterization of a bipotent T cell and NK cell progenitor in the mouse fetal thymus.

@article{Michie2000ClonalCO,
  title={Clonal characterization of a bipotent T cell and NK cell progenitor in the mouse fetal thymus.},
  author={Alison M Michie and James R. Carlyle and Thomas M Schmitt and Belma Ljutic and Sarah K R Cho and Q Fong and Juan Carlos Z{\'u}{\~n}iga-Pfl{\"u}cker},
  journal={Journal of immunology},
  year={2000},
  volume={164 4},
  pages={1730-3}
}
We recently described a population of fetal thymocytes with a CD117+NK1.1+CD90lowCD25- phenotype, which were shown to contain committed T cell and NK cell progenitors. However, the characterization of a single cell with a restricted T and NK cell precursor potential was lacking. Here, using an in vitro model for T and NK cell differentiation, we provide conclusive evidence demonstrating the existence of a clonal lineage-restricted T and NK cell progenitor. These results establish that fetal… CONTINUE READING

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