Clonal architecture of the mouse hippocampus.

  title={Clonal architecture of the mouse hippocampus.},
  author={Loren A. Martin and S Z Tan and Dan Goldowitz},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={22 9},
Experimental mouse chimeras have proven useful in analyzing the cell lineages of various tissues. Here we use experimental mouse chimeras to study cell lineage of the hippocampus. We examined clonal architecture and lineage relationships of the hippocampal pyramidal cells, dentate granule cells, and GABAergic interneurons. We quantitatively analyzed like-genotype cohorts of these neuronal populations in the hippocampus of the most highly skewed chimeras to provide estimates of the size of the… CONTINUE READING


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