Clonal architecture of normal and atherosclerotic aorta: implications for atherogenesis and vascular development.

@article{Chung1998ClonalAO,
  title={Clonal architecture of normal and atherosclerotic aorta: implications for atherogenesis and vascular development.},
  author={I M Chung and Stephen M Schwartz and Charles E Murry},
  journal={The American journal of pathology},
  year={1998},
  volume={152 4},
  pages={913-23}
}
X chromosome inactivation studies indicate that smooth muscle cells in human atherosclerosis are monoclonal. Monoclonality could arise either by 1) proliferation of a single cell in the adult intima, eg, by selection or mutation, or 2) proliferation of many cells within a large, pre-existing clonal patch that formed during development. To determine whether… CONTINUE READING