Clonal and microclonal mutational heterogeneity in high hyperdiploid acute lymphoblastic leukemia

@inproceedings{Smith2016ClonalAM,
  title={Clonal and microclonal mutational heterogeneity in high hyperdiploid acute lymphoblastic leukemia},
  author={Adam J de Smith and Juhi Ojha and Stephen Starko Francis and Erica Marie Sanders and Alyson A. Endicott and Helen M. Hansen and Ivan V. Smirnov and Amanda M. Termuhlen and Kyle M. Walsh and Catherine Metayer and Joseph Wiemels},
  booktitle={Oncotarget},
  year={2016}
}
High hyperdiploidy (HD), the most common cytogenetic subtype of B-cell acute lymphoblastic leukemia (B-ALL), is largely curable but significant treatment-related morbidity warrants investigating the biology and identifying novel drug targets. Targeted deep-sequencing of 538 cancer-relevant genes was performed in 57 HD-ALL patients lacking overt KRAS and NRAS hotspot mutations and lacking common B-ALL deletions to enrich for discovery of novel driver genes. One-third of patients harbored… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS