Clonal analysis of patterns of growth, stem cell activity, and cell movement during the development and maintenance of the murine corneal epithelium.

@article{Collinson2002ClonalAO,
  title={Clonal analysis of patterns of growth, stem cell activity, and cell movement during the development and maintenance of the murine corneal epithelium.},
  author={Jon Martin Collinson and Lucy Morris and Alasdair I Reid and Thaya Ramaesh and Margaret A. Keighren and Jean H. Flockhart and Robert E Hill and S Z Tan and Kanna Ramaesh and Baljean Dhillon and John D. West},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2002},
  volume={224 4},
  pages={432-40}
}
Patterns of growth and cell movement in the developing and adult corneal epithelium were investigated by analysing clonal patches of LacZ-expressing cells in chimeric and X-inactivation mosaic mice. It was found that cell proliferation throughout the basal corneal epithelium during embryogenesis and early postnatal life creates a disordered mosaic pattern of LacZ(+) clones that contrasts with patterns of proliferation and striping produced during the later embryonic stages of retinal pigmented… CONTINUE READING
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