Clonal analysis of intrahepatic B cells from HCV-infected patients with and without mixed cryoglobulinemia.

@article{Sansonno1998ClonalAO,
  title={Clonal analysis of intrahepatic B cells from HCV-infected patients with and without mixed cryoglobulinemia.},
  author={Domenico E. Sansonno and Salvatore de Vita and A R Iacobelli and V Cornacchiulo and Mauro Boiocchi and Franco Dammacco},
  journal={Journal of immunology},
  year={1998},
  volume={160 7},
  pages={3594-601}
}
Clonal rearrangements of Ig heavy chain (IgH) genes and hepatitis C virus (HCV) genomic sequences were assayed on intrahepatic B lymphocytes isolated from HCV chronically infected patients with and without type II mixed cryoglobulinemia (MC). Liver tissue samples from eight patients with and nine without MC were subjected to routine histologic studies, immunophenotyping, and genotypic analysis including IgH V-D-J region gene rearrangements by PCR. RT-PCR, signal amplification by branched DNA… CONTINUE READING