Clonal analysis of a human antibody response. Quantitation of precursors of antibody-producing cells and generation and characterization of monoclonal IgM, IgG, and IgA to rabies virus

@article{Ueki1990ClonalAO,
  title={Clonal analysis of a human antibody response. Quantitation of precursors of antibody-producing cells and generation and characterization of monoclonal IgM, IgG, and IgA to rabies virus},
  author={Yasuyoshi Ueki and Ilia Goldfarb and Nagaradona Harindranath and Michael Gore and Hilary Koprowski and Abner Louis Notkins and Paolo Casali},
  journal={The Journal of Experimental Medicine},
  year={1990},
  volume={171},
  pages={19 - 34}
}
We quantitated and characterized the changes in the human B cell repertoire, at the clonal level, before and after immunization with rabies virus. Moreover, we generated 10 monoclonal cell lines producing IgM, IgG, and IgA antibodies to the virus. We found that in healthy subjects, not previously exposed to the virus, nearly 2% of the circulating B lymphocytes were committed to the production of antibodies that bound the virus. These B cells expressed the surface CD5 molecule. The antibodies… CONTINUE READING
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