Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes

@article{Xue2015ClonalAA,
  title={Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes},
  author={Ruidan Xue and Matthew D Lynes and Jonathan M. Dreyfuss and Farnaz Shamsi and Tim J Schulz and Hongbin Zhang and Tian Lian Huang and Kristy L Townsend and Yiming Li and Hirokazu Takahashi and Lauren S Weiner and Andrew P. White and Maureen S. Lynes and Lee L Rubin and Laurie J Goodyear and Aaron M Cypess and Yu-Hua Tseng},
  journal={Nature Medicine},
  year={2015},
  volume={21},
  pages={760-768}
}
Targeting brown adipose tissue (BAT) content or activity has therapeutic potential for treating obesity and the metabolic syndrome by increasing energy expenditure. However, both inter- and intra-individual differences contribute to heterogeneity in human BAT and potentially to differential thermogenic capacity in human populations. Here we generated clones of brown and white preadipocytes from human neck fat and characterized their adipogenic and thermogenic differentiation. We combined an… CONTINUE READING

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