Clonal V alpha 12.1+ T cell expansions in the peripheral blood of rheumatoid arthritis patients

@article{Dersimonian1993ClonalVA,
  title={Clonal V alpha 12.1+ T cell expansions in the peripheral blood of rheumatoid arthritis patients},
  author={H Dersimonian and Masahiko Sugita and David N. Glass and Agnes L. Maier and Michael E. Weinblatt and Thierry R{\'e}me and Michael B Brenner},
  journal={The Journal of Experimental Medicine},
  year={1993},
  volume={177},
  pages={1623 - 1631}
}
Rheumatoid arthritis (RA) represents a heterogenous disease characterized by chronic polyarthritis. Most patients with adult RA inherit HLA-DR4 or -DR1 major histocompatibility complex (MHC) genes. While the molecular basis for this genetic predisposition is unknown, the major function of these MHC-encoded molecules is to present peptides to T lymphocytes. It is hypothesized that an endogenous or environmental antigen initiates a MHC-restricted immune response mediated by T lymphocytes, which… CONTINUE READING