Clonal Hematopoiesis Associated With Adverse Outcomes After Autologous Stem-Cell Transplantation for Lymphoma.

  title={Clonal Hematopoiesis Associated With Adverse Outcomes After Autologous Stem-Cell Transplantation for Lymphoma.},
  author={Christopher J. Gibson and R Coleman Lindsley and Vatche Tchekmedyian and Brenton G Mar and Jiantao Shi and Siddhartha Jaiswal and Alysia Bosworth and Liton Francisco and Jianbo He and Anita Bansal and Elizabeth A Morgan and Ann S Lacasce and Arnold Stephen Freedman and David C. Fisher and Eric D. Jacobsen and Philippe F Armand and Edwin P Alyea and John Koreth and Vincent Ho and Robert J. Soiffer and Joseph H Antin and Jerome Ritz and Sarah Nikiforow and Stephen J. Forman and Franziska Michor and Donna S Neuberg and Ravi Bhatia and Shailender Bhatia and Benjamin L. Ebert},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  volume={35 14},
Purpose Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related condition characterized by somatic mutations in the blood of otherwise healthy adults. We hypothesized that in patients undergoing autologous stem-cell transplantation (ASCT) for lymphoma, CHIP at the time of ASCT would be associated with an increased risk of myelodysplastic syndrome and acute myeloid leukemia, collectively termed therapy-related myeloid neoplasm (TMN), and other adverse outcomes. Methods We… CONTINUE READING
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