Clonal Hematopoiesis Associated With Adverse Outcomes After Autologous Stem-Cell Transplantation for Lymphoma.

@article{Gibson2017ClonalHA,
  title={Clonal Hematopoiesis Associated With Adverse Outcomes After Autologous Stem-Cell Transplantation for Lymphoma.},
  author={Christopher J. Gibson and R Coleman Lindsley and Vatche Tchekmedyian and Brenton G Mar and Jiantao Shi and Siddhartha Jaiswal and Alysia Bosworth and Liton Francisco and Jianbo He and Anita Bansal and Elizabeth A Morgan and Ann S Lacasce and Arnold Stephen Freedman and David C. Fisher and Eric D. Jacobsen and Philippe F Armand and Edwin P Alyea and John Koreth and Vincent Ho and Robert J. Soiffer and Joseph H Antin and Jerome Ritz and Sarah Nikiforow and Stephen J. Forman and Franziska Michor and Donna S Neuberg and Ravi Bhatia and Shailender Bhatia and Benjamin L. Ebert},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2017},
  volume={35 14},
  pages={
          1598-1605
        }
}
Purpose Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related condition characterized by somatic mutations in the blood of otherwise healthy adults. We hypothesized that in patients undergoing autologous stem-cell transplantation (ASCT) for lymphoma, CHIP at the time of ASCT would be associated with an increased risk of myelodysplastic syndrome and acute myeloid leukemia, collectively termed therapy-related myeloid neoplasm (TMN), and other adverse outcomes. Methods We… CONTINUE READING
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References

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Showing 1-10 of 24 references

Leukemiaassociated somaticmutations drive distinct patterns of agerelated clonal hemopoiesis

  • T McKerrell, N Park, T Moreno
  • Cell Rep 10:1239-1245,
  • 2015
2 Excerpts

Role of TP53mutations in theorigin and evolution of therapyrelated acute myeloid leukaemia

  • TN Wong, G Ramsingh, AL Young
  • Nature 518:552-555,
  • 2015

Age-relatedmutations associated with clonal hematopoietic expansion and malignancies

  • XieM, LuC, J Wang
  • Nat Med
  • 2014
2 Excerpts

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