Clonal Expansion of Lymphocytes Bearing the ‘y#{246} T-Cell Receptor in a Patient With Large Granular Lymphocyte Disorder

Abstract

Repeated analysis of peripheral blood lymphocytes (PBLs) from a patient with large granular lymphocytosis. neutropenia, and rheumatoid arthritis revealed that -45% of PBLs displayed the following phenotype: CD3 , CD4, CDS. CD1 6 . HNK-1 -, WT31 -. This population was purified for further analysis by depletion with anti-CD4 and anti-CD8 monoclonal antibodies… (More)

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