Clonal Evolution and Therapeutic Resistance in Solid Tumors

Abstract

Tumors frequently arise as a result of an acquired genomic instability and the subsequent evolution of neoplastic populations with variable genomes. A barrier to the study of the somatic genetics of human solid tumors in vivo is the presence of admixtures of non-neoplastic cells with normal genomes in patient samples. These can obscure the presence of… (More)
DOI: 10.3389/fphar.2013.00002

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