Clonal Architectures and Driver Mutations in Metastatic Melanomas


To reveal the clonal architecture of melanoma and associated driver mutations, whole genome sequencing (WGS) and targeted extension sequencing were used to characterize 124 melanoma cases. Significantly mutated gene analysis using 13 WGS cases and 15 additional paired extension cases identified known melanoma genes such as BRAF, NRAS, and CDKN2A, as well as… (More)
DOI: 10.1371/journal.pone.0111153


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@inproceedings{Ding2014ClonalAA, title={Clonal Architectures and Driver Mutations in Metastatic Melanomas}, author={Li Ding and Minjung Kim and Krishna Latha Kanchi and Nathan D. Dees and Charles Lu and Malachi Griffith and David Fenstermacher and Hyeran Sung and Christopher A Miller and Brian Goetz and Michael C. Wendl and O. Mitch Griffith and Lynn A. Cornelius and Gerald P. Linette and Joshua F. McMichael and Vernon K. Sondak and Ryan Courtney Fields and Timothy J. Ley and James J. Mul{\'e} and Richard K. Wilson and Jeffrey S. Weber}, booktitle={PloS one}, year={2014} }