Clonable progenitors committed to the T lymphocyte lineage in the mouse bone marrow; use of an extrathymic pathway.

Abstract

We searched for clonable committed T cell progenitors in the adult mouse bone marrow and isolated rare (approximately 0.05%) cells with the Thy-1hiCD2-CD16+CD44hiCD25-Lin- phenotype. In vivo experiments showed that these cells were progenitors committed only to reconstituting the T cell lineage of irradiated Ly5 congenic hosts. Reconstitution of the thymus… (More)

Topics

5 Figures and Tables

Cite this paper

@article{DejbakhshJones2001ClonablePC, title={Clonable progenitors committed to the T lymphocyte lineage in the mouse bone marrow; use of an extrathymic pathway.}, author={Sussan Dejbakhsh-Jones and Marcos E. Garc{\'i}a-Ojeda and Devavani Chatterjea-Matthes and Defu Zeng and Samuel Strober}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2001}, volume={98 13}, pages={7455-60} }