Clomipramine vs desipramine vs placebo in the treatment of diabetic neuropathy symptoms. A double-blind cross-over study.

@article{Sindrup1990ClomipramineVD,
  title={Clomipramine vs desipramine vs placebo in the treatment of diabetic neuropathy symptoms. A double-blind cross-over study.},
  author={S{\o}ren Hein Sindrup and LarsF. Gram and Tina Skjold and Ellen Grodum and Kim Br{\o}sen and Henning Beck-Nielsen},
  journal={British journal of clinical pharmacology},
  year={1990},
  volume={30 5},
  pages={
          683-91
        }
}
1. The effect of clomipramine and desipramine on diabetic neuropathy symptoms was examined in a double-blind, randomised, placebo controlled, cross-over study for 2 + 2 + 2 weeks. Drug doses were adjusted according to the sparteine phenotype, i.e. extensive metabolisers were treated with 75 mg clomipramine day-1 and 200 mg desipramine day-1 whereas poor metabolisers were treated with 50 mg day-1 of both drugs. Nineteen patients completed the study. 2. Plasma concentration of clomipramine plus… CONTINUE READING
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