Clomipramine and clonazepam increase cholecystokinin levels in rat ventral tegmental area and limbic regions.

@article{Brodin1994ClomipramineAC,
  title={Clomipramine and clonazepam increase cholecystokinin levels in rat ventral tegmental area and limbic regions.},
  author={Kerstin Brodin and Sven Ove {\"O}gren Ogren and Ernst Brodin},
  journal={European journal of pharmacology},
  year={1994},
  volume={263 1-2},
  pages={
          175-80
        }
}
Recent reports suggest that a cholecystokinin (CCK)-related dysfunction may be a target by which drugs can modulate anxiety and panic disorders. In the present study, effects of subchronic (14 days) treatment with the monoamine uptake inhibitors nortriptyline (30 mumol/kg per day), amitriptyline (29 mumol/kg per day), clomipramine (32 mumol/kg per day) and alaproclate (39 mumol/kg per day), as well as with the benzodiazepine clonazepam (0.25 mumol/kg per day), on rat brain levels of CCK- and… CONTINUE READING
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