Clomiphene and hypospadias on a detailed level: signal or chance?

@article{Meijer2006ClomipheneAH,
  title={Clomiphene and hypospadias on a detailed level: signal or chance?},
  author={Willemijn M. Meijer and Lolkje de Jong-van den Berg and Marjan D van den Berg and Joke B. G. M. Verheij and Hermien E K De Walle},
  journal={Birth defects research. Part A, Clinical and molecular teratology},
  year={2006},
  volume={76 4},
  pages={
          249-52
        }
}
BACKGROUND Clomiphene, a drug used to induce ovulation, is chemically related to diethylstilbestrol (DES). DES is associated with vaginal cancer and infertility among daughters and with hypospadias among second-generation male offspring. Because clomiphene has a long half-life and metabolites have been found in feces up to 6 weeks after administration, fetal exposure is possible if the mother took this drug prior to becoming pregnant. METHODS Case-control analyses were performed to… CONTINUE READING

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Risk factors for hypospadias

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Aetiology of hypospadias : A systematic review of genes and environment RUNNING TITLE : Hypospadias aetiology

I. A. L. M. van Rooija, W. F. J. Feitzc, +3 authors N. Roelevelda
  • 2017
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