Clomiphene administration for cases of nonobstructive azoospermia: a multicenter study.

  title={Clomiphene administration for cases of nonobstructive azoospermia: a multicenter study.},
  author={Alayman F Hussein and Yaşar Ozgok and Lawrence Ross and Craig Niederberger},
  journal={Journal of andrology},
  volume={26 6},
  pages={787-91; discussion 792-3}
Clomiphene citrate is a well-established agent that has been empirically used in cases of idiopathic oligospermia. Clomiphene increases endogenous gonadotropin-releasing hormone secretion from the hypothalamus and gonadotropin hormone secretion directly from the pituitary and, thus, increases intratesticular testosterone concentration. Using intracytoplasmic sperm injection (ICSI), very few sperm may be required for fertilization. The objective of this study was to determine if the application… CONTINUE READING


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