Clofibrate pretreatment diminishes acetaminophen's selective covalent binding and hepatotoxicity.

@article{Manautou1994ClofibratePD,
  title={Clofibrate pretreatment diminishes acetaminophen's selective covalent binding and hepatotoxicity.},
  author={Jos{\'e} Enrique Manautou and Debie J Hoivik and Arnljot Tveit and S. G. Hart and Edward A. Khairallah and Steven D. Cohen},
  journal={Toxicology and applied pharmacology},
  year={1994},
  volume={129 2},
  pages={
          252-63
        }
}
Peroxisome proliferators have been shown to diminish acetaminophen (APAP) hepatotoxicity (Biochem. Pharmacol. 43, 1395, 1992). To investigate the mechanistic basis for this protection CD-1 male mice were given corn oil or 500 mg clofibrate (CFB)/kg, ip, daily for 10 days. They were then fasted overnight and either killed without challenge or at 4 or 12 hr after challenge with 800 mg APAP/kg (in 50% propylene glycol). At 12 hr, hepatotoxicity was evidenced by elevated plasma sorbitol… CONTINUE READING
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