Clofibrate and di(2-ethylhexyl)phthalate increase ubiquinone contents without affecting cholesterol levels.

  title={Clofibrate and di(2-ethylhexyl)phthalate increase ubiquinone contents without affecting cholesterol levels.},
  author={Fredrik {\AA}berg and E. L. Appelkvist},
  journal={Acta biochimica Polonica},
  volume={41 3},
Induction studies were performed on liver, muscle, heart, brain and blood by feeding Sprague-Dawley rats a diet containing a peroxisome proliferator, clofibrate or di(2-ethylhexyl)phthalate. Ingestion of these drugs resulted in an increase in the amount of two different types of ubiquinone homologues UQ9 and UQ10 found in rat. Phthalate proved to be the more effective drug, leading to a highly increased amount of ubiquinone in the liver. Increases were also found in all the above-mentioned… 
Molecular Mechanisms Associated with the Induction of Ubiquinone by Peroxisome Proliferators
  • S. Khan
  • Biology, Chemistry
    Gastroenterology research
  • 2009
A marked increase in hepatic ubiquinone was observed in wild-type mice exposed to a peroxisome proliferator, diethylhexylphthalate (DEHP), andtracer studies with [3H] mevalonate precursor indicated that the increase of ubiquin one by DEHP was a result of increased biosynthesis.
Clofibrate-induced gene expression changes in rat liver: a cross-laboratory analysis using membrane cDNA arrays.
The potential for gene expression profiling to identify toxic hazards by the identification of mechanistically relevant markers of toxicity is demonstrated, and some variability in the quantitative nature of the microarray data is indicated.
Regulation of Coenzyme Q Biosynthesis Pathway in Eukaryotes.


Distribution and redox state of ubiquinones in rat and human tissues.
Studies on the biosynthesis of polyisoprenols, cholesterol and ubiquinone in highly differentiated human hepatomas.
The results in this study of hepatomas indicate that the levels of various lipids may be influenced not only by the regulatory enzyme HMG-CoA reductase, but also by other enzymes catalysing reactions subsequent to this regulatory point.
Lipid compositions of intracellular membranes isolated from rat liver nodules in Wistar rats.
The alterations found in the lipid composition of liver nodules are significant and have functional implications in many cellular processes of proposed importance for the carcinogenic process, i.e., protein glycosylation cholesterogenesis, regulation of the mevalonate pathway, cellular oxidation-reduction state, and resistance to oxidative stress.
Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations.
  • B. FreiM. C. KimB. Ames
  • Chemistry, Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1990
The data together with previous work on the antioxidant function of ubiquinol reported in the literature strongly suggest that ubiqu inol-10 is an important physiological lipid-soluble antioxidant.
Concentration-dependent antioxidant activity of probucol in low density lipoproteins in vitro: probucol degradation precedes lipoprotein oxidation.
In vitro findings suggest that the potent antioxidant property of probucol is directly related to the amount of drug in the LDL particle and may have relevance to its antiatherosclerotic effects observed in vivo.
Studies with ubiquinone-depleted submitochondrial particles. Essentiality of ubiquinone for the interaction of succinate dehydrogenase, NADH dehydrogenase, and cytochrome b.
It is concluded that uniquinone is essential for the interaction of succinate dehydrogenase, NADH dehydrogenases and cytochrome b, and that this interaction is a requisite for the normal function of the respiratory chain.