Clofazimine: a review of its medical uses and mechanisms of action.

@article{Arbiser1995ClofazimineAR,
  title={Clofazimine: a review of its medical uses and mechanisms of action.},
  author={Jack L. Arbiser and Samuel L Moschella},
  journal={Journal of the American Academy of Dermatology},
  year={1995},
  volume={32 2 Pt 1},
  pages={241-7}
}
Clofazimine has been in clinical use for almost 40 years, but little is known of its mechanism of action. The primary indication for clofazimine is multibacillary leprosy, but it is useful in several infectious and noninfectious diseases, such as typical myocobacterial infections, rhinoscleroma, pyoderma gangrenosum, necrobiosis lipoidica, severe acne, pustular psoriasis, and discoid lupus erythematosus. Postulated mechanisms of action include intercalation of clofazimine with bacterial DNA and… CONTINUE READING

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