Clofarabine 5 ′-di and-triphosphates inhibit human ribonucleotide reductase by altering the quaternary structure of its large subunit

@inproceedings{Ayea2011Clofarabine5,
  title={Clofarabine 5 ′-di and-triphosphates inhibit human ribonucleotide reductase by altering the quaternary structure of its large subunit},
  author={Yimon Ayea and JoAnne Stubbea},
  year={2011}
}
  • Yimon Ayea, JoAnne Stubbea
  • Published 2011
Human ribonucleotide reductases (hRNRs) catalyze the conversion of nucleotides to deoxynucleotides and are composed of αand β-subunits that form active αnβm (n,m 1⁄4 2 or 6) complexes. α binds NDP substrates (CDP, UDP, ADP, and GDP, C site) as well as ATP and dNTPs (dATP, dGTP, TTP) allosteric effectors that control enzyme activity (A site) and substrate… CONTINUE READING