Clockworks in the Central and Peripheral Organs: from Clock-related Genes to the Physiological and Pathological Rhythms

@inproceedings{Moriya2003ClockworksIT,
  title={Clockworks in the Central and Peripheral Organs: from Clock-related Genes to the Physiological and Pathological Rhythms},
  author={Takahiro Moriya and Kazuyuki Shinohara},
  year={2003}
}
Daily rhythms such as sleep-wake, feeding, and the core body temperature, persist with a period of approximately 24 hr even in the absence of environmental time cues, suggesting the existence of an endogenous time-keeping system , the circadian clock. In mammals, the circadian clock is located in the suprachiasmatic nucleus of the hypothalamus (SCN). Recently, a number of studies have revealed that circadian oscillations in the SCN are driven by the intracel-lular transcriptional and post… CONTINUE READING

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