Clockwork Orange is a transcriptional repressor and a new Drosophila circadian pacemaker component.

@article{Kadener2007ClockworkOI,
  title={Clockwork Orange is a transcriptional repressor and a new Drosophila circadian pacemaker component.},
  author={Sebasti{\'a}n Kadener and Dan Stoleru and Michael P. McDonald and Pipat Nawathean and Michael Rosbash},
  journal={Genes & development},
  year={2007},
  volume={21 13},
  pages={1675-86}
}
Many organisms use circadian clocks to keep temporal order and anticipate daily environmental changes. In Drosophila, the master clock gene Clock promotes the transcription of several key target genes. Two of these gene products, PER and TIM, repress CLK-CYC-mediated transcription. To recognize additional direct CLK target genes, we designed a genome-wide approach and identified clockwork orange (cwo) as a new core clock component. cwo encodes a transcriptional repressor that synergizes with… CONTINUE READING
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