Clockwise domain arrangement of the sodium channel revealed by (mu)-conotoxin (GIIIA) docking orientation.

  title={Clockwise domain arrangement of the sodium channel revealed by (mu)-conotoxin (GIIIA) docking orientation.},
  author={Ronald A. Li and Irene L Ennis and Robert J. French and Samuel C Dudley and Gordon F. Tomaselli and Eduardo Marb{\'a}n},
  journal={The Journal of biological chemistry},
  volume={276 14},
mu-Conotoxins (mu-CTXs) specifically inhibit Na(+) flux by occluding the pore of voltage-gated Na(+) channels. Although the three-dimensional structures of mu-CTXs are well defined, the molecular configuration of the channel receptor is much less certain; even the fundamental question of whether the four homologous Na(+) channel domains are arranged in a clockwise or counter-clockwise configuration remains unanswered. Residues Asp(762) and Glu(765) from domain II and Asp(1241) from domain III… CONTINUE READING


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Recept. Channels 3, 164–74 Clockwise Arrangement of the Sodium Channel Domains

  • M. Chahine, Chen, +5 authors R. G. Kallen
  • 1995

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