Clocks and switches: bacterial gene regulation by DNA adenine methylation.

@article{Low2008ClocksAS,
  title={Clocks and switches: bacterial gene regulation by DNA adenine methylation.},
  author={David A. Low and Josep M Casades{\'u}s},
  journal={Current opinion in microbiology},
  year={2008},
  volume={11 2},
  pages={106-12}
}
N(6) methylation in adenosine moieties causes changes in DNA structure and can modulate DNA-protein interactions. In both alpha-Proteobacteria and gamma-Proteobacteria, postreplicative formation of N(6)-methyl-adenine regulates transcription of specific genes and provides two general types of controls: (i) clock-like controls that permit transient gene transcription during a specific stage of DNA replication; (ii) switch-like controls in which transcription is regulated by a DNA methylation… CONTINUE READING
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