Clock genes regulate neurogenic transcription factors, including NeuroD1, and the neuronal differentiation of adult neural stem/progenitor cells.

@article{Kimiwada2009ClockGR,
  title={Clock genes regulate neurogenic transcription factors, including NeuroD1, and the neuronal differentiation of adult neural stem/progenitor cells.},
  author={Tomomi Kimiwada and Mikako Sakurai and Hiroki Ohashi and Shunsuke Aoki and Teiji Tominaga and Keiji Wada},
  journal={Neurochemistry international},
  year={2009},
  volume={54 5-6},
  pages={277-85}
}
The circadian clock system plays multiple roles in our bodies, and clock genes are expressed in various brain regions, including the lateral subventricular zone (SVZ) where neural stem/progenitor cells (NSPCs) persist and postnatal neurogenesis continues. However, the functions of clock genes in adult NSPCs are not well understood. Here, we first investigated the expression patterns of Clock and Bmal1 in the SVZ by immunohistochemistry and then verified how the expression levels of 17 clock and… CONTINUE READING

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